Suman Shrestha, PhD
Resident (Medical Physics)
Radiation Physics, Division of Radiation Oncology
University of Texas MD Anderson Cancer Center
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Chair | Working Group on Communications
International Society of Radiation Epidemiology and Dosimetry [ISoRED]
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Email:
sshrestha1@mdanderson.org
inspirephysics@gmail.com
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Office Address:
Faculty Center Tower (FCT),
1400 Pressler St, Houston, TX 77030
BACKGROUND
Dr. Shrestha is a pediatric cancer researcher with a focus on radiation therapy-related late-cardiovascular disease. He is currently a Medical Physics Resident in the radiation physics department at MD Anderson Cancer Center. Dr. Shrestha has been recognized for his work by many medical associations and has subsequently been emerging as an important voice in the field of late effects of radiation therapy.
He is the current Chair of Working group on communications (WGC) in the International Society of Radiation Epidemiology and Dosimetry (ISoRED). His goal is to become an independent researcher, licensed medical physicist, and tenured professor. He plans to contribute to health care reform in developing countries and is committed to producing the next generation of medical physicists and pediatric health scientists.
EDUCATION
2018-2022
Doctor of Philosophy
Medical Physics
GPA: 4.00
UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER UT HEALTH GSBS
PhD Project: "Infrastructure Development for Prospective Optimization of Radiation Therapy to Reduce the Future Risk of Cardiac Disease"
Advisor: Prof. Rebecca M. Howell, PhD, DABR, FAAPM
2015-2018
Master's Degree
Medical Physics
GPA: 3.85
LOUISIANA STATE UNIVERSITY
Thesis Title: "Analytical Models of Neutron Spectral Fluence, Kerma and Absorbed Dose For ProtonTherapy"
Advisor: Prof. Wayne D. Newhauser, PhD, DABR, FAAPM, FAAAS
2010-2013
Master's Degree
Physics
TRIBHUVAN UNIVERSITY
Central Department of Physics [Best Gradaute School in Nepal]
Double Major: Advanced Solid State Physics and Biomedical Physics
2006-2010
Bachelor's Degree
Physics
TRIBHUVAN UNIVERSITY
Major: Physics | Minors: Chemistry & Math
BOARD CERTIFICATION
2017
ABR I
CERTIFICATE IN THERAPEUTIC MEDICAL PHYSICS
American Board of Radiology in Medical Physics, Part I , Complete
EXPERIENCE & SERVICE
2023-Present
Resident (Medical Physics)
MD ANDERSON CANCER CENTER
Clinical radiation oncology physics training under the supervision of board certified medical physicists gaining experience with full range of state of the art radiation oncology procedures, techniques and equipment.
2022-2023
Postdoctoral Research Fellow
MD ANDERSON CANCER CENTER
Worked on NIH funded (R0-1) project : Personalized Risk Prediction to Reduce Cardiovascular Disease in Childhood Cancer Survivors developing risk prediction models and integrating them into clinical treatment planning system for routine clinical use. Also worked on developing computational phantom library for late effects studies.
2018-2022
Graduate Research Assistant
MD ANDERSON CANCER CENTER & UTHEALTH GRADUATE SCHOOL OF BIOMEDICAL SCIENCES
As a member of Late Effects Research Group, his focus has been developing a new anatomy based cardiac model with substructure definition to facilitate cardiac toxicity research. He is devising computational organ models and novel dosimetry methodologies for patients who have undergone contemporary radiation therapy. This will enable unique and unprecedented late-effects studies. Data from such studies will significantly improve the understanding of impact of advanced radiotherapy on late effects.
2017-2018
Graduate Research Assistant
LOUISIANA STATE UNIVERSITY
At LSU, his research focused on developing models to accurately calculate the stray radiation in proton therapy, i.e., dose outside the treatment beam due to neutron contamination. The goal of my thesis project was to create a physics-based model, generally applicable, and computationally efficient to enable routine clinical calculations of the many sources of stray neutron dose. This information will enable accurate risk calculations in both retrospective and prospective cases.
2015-2017
Graduate Teaching Assistant
LOUISIANA STATE UNIVERSITY
He had worked as TA for graduate course MEDP 7121: Radiation Biology. Taught undergraduate physics lab, Phys-2109: Introductory Electricity and Magnetism Lab and general physics course Phys-2002: Electricity and Magnetism, general physics course. Responsibilities included teaching basic physics principles, instructing during lab, grading their reports and writing and grading Finals.
2014-2015
Lecturer in Physics
Academic Advisor
NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY, NEPAL
Responsibilities as lecturer included teaching lectures in Physics and instructing students in laboratory ,question setting, grading, conducting conferences and seminars etc. Also responsible for advising and counselling of students in science group which involved conducting meetings with guardians, one to one session with students, getting feedback from other professors etc.
HONORS & AWARDS
2023 Best Oral Presentation (3rd Place), Trainee Research Day, MD Anderson Cancer Center
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2022 Science Council Associate Mentorship Program (SCAMP), AAPM
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2022 Dade W. Moeller Scholarship in Health Physics 2022-2023, Health Physics Society
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2022 Jesse B. Heath, Jr. Family Legacy Award, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
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2022 GSBS/MDACC Travel Award [Career Development], The University of Texas MD Anderson Cancer Center UTHealth
Graduate School of Biomedical Sciences
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2021 Young Investigator, Cardiovascular Research, Pediatric Normal Tissue Effects in Clinic (PENTEC)
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2021 Virtual Conference Award, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
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2021 ACR Medical Physics Graduate Scholarship, American College of Radiology (ACR)
2021 Winner (1st Place) - MedPhys SLAM Competition, South West American Association of Physicist in Medicine SWAAPM
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2021 Best Physics Publication, Department of Radiation Physics, MD Anderson Cancer Center, Awarded the MD Anderson Cancer Center Radiation Physics Publication of the Month (Nov/Dec 2020) for outstanding research.
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2020 Robert S. Landauer, Sr. Fellowship in Health Physics 2020-2021, Health Physics Society
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2020 Health Physics Society Travel Grant 2021, Health Physics Society
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2020 Chair-Elect (2021), Vice-Chair (2020), Working Group on Student and Trainee Research, American Association of Physicist in Medicine (AAPM)
2020 Radiation Oncology Commendation, Section of Outreach Physics, Division of Radiation Oncology, UT MD Anderson Cancer Center
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2020 UT Health Science Center, Graduate School of Biomedical Sciences International Travel Award, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
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2020 Best Poster Award [Winner], 2nd Author, Southwest Regional Chapter of American Association of Physicist in Medicine
2020 Best Poster Award [2nd Runner Up], Southwest Regional Chapter of American Association of Physicist in Medicine
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2019 Sylvan Rodriguez Foundation Scholarship honoring George M. Stancel, Ph.D. 2019-2020, UTHealth GSBS
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2019 NCI International Fellowship [ISORED], National Cancer Institute, Maryland, USA
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2019 Marilyn and Frederick R. Lummis, Jr. M.D., Fellowship in the Biomedical Sciences 2019-2020, UTHealth GSBS
2019 UT Health Science Center, Graduate School of Biomedical Sciences Travel Award, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
2019 Expanding Horizons Travel Grant Award, American Association of Physicist in Medicine
2018 Childhood Cancer Survivor Study (CCSS) Career Development Award 2018-2019, St. Jude Children’s Research Hospital
2018 Health Physics Society Travel Grant [Schedule Conflict with Thesis Defense]
2017 Health Physics Society Travel Grant, Awarded and attended the HPS Annual Meeting in Raleigh, NC Health Physics Society
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2010 Merit List Student, Central Department of Physics, Tribhuvan University, Best Physics Graduate School in Nepal
2005-09 Merit Based Scholarship for Deserving Student, Awarded during Proficiency Certificate Level and Bachelor’s Degree, Amrit Science College, Tribhuvan University, Nepal
2004 Excellence in Academia-Top 3 Student, Vishwa Niketan Higher Secondary School, Nepal
2004 Jana-Kalyan Scholarship for Poor and Deserving Student, Jana-Kalyan Foundation, Nepal
PROFESSIONAL MEMBERSHIPS
International Training and Research Coordination Subcommittee (ITRCS)
Guest Member, 01/2020 – 12/2020
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European Society of Radiation Oncology (ESTRO)
Student Member, 2020 – 2021
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Student and Trainees Subcommittee (STSC)
WGSTR Liaison, 2020 – Present
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Work Group on Student and Trainee Research (WGSTR)
Chair 2021, Vice-Chair 2019-20, Member, 2019 – Present
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American College of Radiology (ACR)
National Training Physicist , 2019 – Present
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American Heart Association (AHA)
Student Member, 2019 – 2020
Council on Epidemiology and Prevention
Membership through AHA, 2019 – 2020
Work Group on Radiation Dosimetry (WGRD)
Guest Member (Non-voting), 07/2019 – 12/2020
American Society of Radiation Oncology
Student Member, 2019 – Present
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Radiation Research Society (RRS)
Scholar in Training, 2017 – Present
Radiological Society of North America (RSNA)
Student Member, 2017 – Present
American Nuclear Society (ANS)
Student Member, 2016 – 2018
Health Physics Society (HPS)
Student Member, 2016 – Present
American Association of Physicist in Medicine (AAPM)
Student Member, 2015 – Present
PEER REVIEWED MANUSCRIPTS
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Bates, JE, Shrestha, S, Liu, Q, Smith, SA, Mulrooney, DA, Leisenring, W, Gibson, T, Robison, L, Chow, E, Oeffinger, K, Armstrong, GT, Constine, LS, Hoppe, BS, Lee, C, Yasui, Y, Howell, RM, “Cardiac Substructure Radiation Dose and Risk of Late Cardiac Disease in Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study”, Journal of Clinical Oncology 2023 (Accepted)
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Bates, JE, Keshavarz, H, Rancati, T, Gagliardi, G, Aznar, MC, Howell, RM, Shrestha, S, Moiseenko, V., Yorke, E., Armenian, S, Kermer, L, Chen, MH, van De Pal, H, Cutter, D, Constine, LS, Hodgson, D., “Cardiac Disease in Childhood Cancer Survivors Treated with Radiotherapy: A PENTEC Systematic Review” IJROBP 2023 , In Press
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Owens CA, Rigaud, B, Ludmir, E, Gupta, AC, Shrestha, S, Paulino, AC, Smith SA, Peterson, CB, Kry, SF, Lee, C, Henderson, TO, Armstrong, GT, Brock, KK, Howell, RM, “Development and validation of a population based colorectal model for radiation dosimetry in late effects studies of survivors of childhood cancer. Radiother Oncol. 2022 Sep 5;176:118-126. PubMed PMID: 36063983.
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Shrestha, S, Newhauser WD, Donahue WP, Perez-Andujar A. Stray neutron radiation exposures from proton therapy: physics-based analytical models of neutron spectral fluence, kerma and absorbed dose. Phys Med Biol. 2022 May 25;. doi: 10.1088/1361-6560/ac7377. PubMed PMID: 35613603.
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Gupta AC, Owens CA, Shrestha S, Lee C, Smith SA, Weathers RE, Netherton T, Balter PA, Kry SF, Followill DS, Griffin KT, Long JP, Armstrong GT, Howell RM. Body region-specific 3D age-scaling functions for scaling whole-body computed tomography anatomy for pediatric late effects studies. Biomed Phys Eng Express. 2022 Feb 1;8(2). doi: 10.1088/2057-1976/ac3f4e. PMID: 34874300.
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Shrestha S., Bates JE, Liu Q, Smith SA, Oeffinger KC, Chow EJ, Gupta AC, Owens CA, Constine LS, Hoppe BS, Leisenring WM, Qiao Y, Weathers RE, Court LE, Pinnix CC, Kry SF, Mulrooney DA, Armstrong GT, Yasui Y, Howell RM. Radiation therapy related cardiac disease risk in childhood cancer survivors: Updated dosimetry analysis from the Childhood Cancer Survivor Study. Radiother Oncol. 2021 Oct;163:199-208. doi: 10.1016/j.radonc.2021.08.012. Epub 2021 Aug 26. PubMed PMID: 34454975; PubMed Central PMCID: PMC9036604.
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Shrestha, S., Gupta AC, Bates JE, Lee C, Owens CA, Hoppe BS, Constine LS, Smith SA, Qiao Y, Weathers RE, Yasui Y, Court LE, Paulino AC, Pinnix CC, Kry SF, Followill DS, Armstrong GT, Howell RM. Development and validation of an age-scalable cardiac model with substructures for dosimetry in late-effects studies of childhood cancer survivors. Radiother Oncol. 2020 Dec;153:163-171. doi: 10.1016/j.radonc.2020.10.017. Epub 2020 Oct 17. PubMed PMID: 33075392; PubMed Central PMCID: PMC8132170.
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Gupta AC, Shrestha S, Owens CA, Smith SA, Qiao Y, Weathers RE, Balter PA, Kry SF, Howell RM. Development of an age-scalable 3D computational phantom in DICOM standard for late effects studies of childhood cancer survivors. Biomed Phys Eng Express. 2020 Nov;6(6). doi: 10.1088/2057-1976/ab97a3. Epub 2020 Sep 29. PubMed PMID: 34584772; PubMed Central PMCID: PMC8475741.
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Newhauser, W.D., Schneider, C., Wilson, L., Shrestha, S., Donahue, W., “A review of analytical models of stray radiation exposures from photon- and proton-beam radiotherapies.” Radiat Prot Dosimetry. 2018 Aug 1;180(1-4):245-251. doi: 10.1093/rpd/ncx245. Review. PubMed PMID: 29177488.
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First Authored
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Shrestha, S. et al., “Prospective Optimization of Radiation Therapy to Reduce the Future Risk of Cardiovascular Disease”, Physics World Conference June 15, 2022 [Short Oral Presentation]
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Shrestha, S. et al., “A Hybrid Approach to Improve the Clinical Utility of Physical Anthropomorphic Phantoms" AAPM 2022, [Poster]
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Shrestha, S. et al., “Stray Neutron Radiation Exposures from Proton Therapy: Physics-Based Analytical Models of Neutron Spectral Fluence, Kerma and Absorbed Dose" AAPM 2022, [Poster]
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Shrestha, S. et al., “Dosimetry for RT-related late cardiovascular Disease Studies" ISoRED 2021, Community Building in Radiation Epidemiology and Dosimetry Webinar Series, International Society of Radiation Epidemiology and Dosimetry [Invited Oral Presentation]
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Shrestha, S. “"Relationship Between Coronary Artery Radiation Doses and Risk of Late Coronary Artery Disease: A Report from the Childhood Cancer Survivor Study (CCSS)" AAPM 2021, [Oral Presentation]
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Shrestha, S. “Risk Score Algorithm to Predict Individual Risk of Future Serious Late Cardiovascular Disease
American Association of Physicist in Medicine (AAPM), Med Phys Oral Slam, AAPM 2021 [Oral Presentation]
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Shrestha, S.” The impact of Expanding Horizons Grant and WGSTR Initiatives in Research Progress of AAPM Trainees” AAPM 2021, Expanding Horizon Sessions, AAPM 2021, [Oral Presentation],
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Shrestha, S.” Development of Risk Score Algorithm to Predict Individual Risk of Future Serious Late Cardiovascular Disease” SWAAPM 2021, Med Phys Slam, [Oral Presentation]
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Shrestha, S. et al.” Impact of Enhanced CT-based Heart Model on Estimating Radiation Therapy Related Late-Onset Cardiac Disease in the Childhood Cancer Survivor Study” Med Phys. 2020; 47; 6: e464 [Blue-ribbon, Snap Oral]
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Shrestha, S. et al., “Development and inter-variability study of computed tomography based computational cardiac models for cardiac dosimetry in late effects studies” International Society for Radiation, Epidemiology and Dosimetry (ISORED) 2020, Sitges, Spain [Short Oral + Discussion + Poster presentation]
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Shrestha, S. et al., “Development of CT-based cardiac model with substructure for dosimetry in late effects studies” Radiotherapy and Oncology, Volume 153, 163 - 171, ESTRO Congress 2020 [Short Oral + Discussion + Poster]
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Shrestha, S. et al., “Computed tomography based computational cardiac models for dosimetry in late effects studies” South West American Association of Physicist in Medicine, SWAAPM 2020 [Poster Presentation]
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Shrestha, S., Howell, R.M. “North American Symposium on Late Effects After Childhood Cancer (NASLCC), CCSS & IGHG Meeting: Expanding Horizon Grant Awardees Perspective”, AAPM 2020, [Short Oral + Poster]
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Shrestha, S., Howell, R.M. “Status of an enhanced heart model with substructures for cardiac dosimetry for late effects studies”, ASTRO Pre-conference Physician Meet, September 14, 2019; Chicago, Michigan [Oral Presentation]
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Shrestha, S. et al., “Development of an enhanced heart model with substructures for cardiac dosimetry for late effects studies”, Med Phys. 2019; 46; 6: e313 [Discussion Session and Poster Presentation]
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Shrestha, S., "Analytical Models of Neutron Spectral Fluence, Kerma and Absorbed-Dose for Proton Therapy" (2018). LSU Master's Theses. 4781.
Co-authored
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Owens C, Rigaud B, Ludmir E, Gupta A, Shrestha S, et al.,” Development and Validation of a Population-Based Anatomical Colorectal Model for Radiation Dosimetry in Late Effects Studies of Childhood Cancer Survivors”, AAPM 2022, [Oral Presentation: John R. Cameron Early-Career Investigator Symposium: 3rd Place Winner]
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Owens C, Rigaud B, Ludmir E, Gupta A, Shrestha S, et al. “Development and validation of a population-based colorectal model for radiation therapy dosimetry, ESTRO 2022, [Oral Presentation]
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Bates J, Shrestha, S. et al. “Impact of Cardiac Substructure Dosimetry on Late Cardiac Risk: A Report from the Childhood Cancer Survivor Study (CCSS): A Report from Childhood Cancer Survivor Study (CCSS): ASTRO 2021 [Oral Presentation]
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Bates J, Shrestha, S. et al. “Impact of Cardiac Substructure Dosimetry on Arrhythmia Risk in Long Term Survivors of Childhood Cancer: A Report from Childhood Cancer Survivor Study (CCSS): ESTRO 2021 [Oral Presentation]
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Owens C., Riguad B., Ludmir E., Gupta, A., Shrestha, S. et al. “From Person-Specific to Population-Based Colorectal Models: An Age-Scalable Computational Anatomical Colorectal Model for Radiation Dosimetry in Late Effects Studies of Childhood Cancer Survivors” AAPM 2021, [Oral Presentation]
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Gupta A., Owens C., Netherton, T., Lee, C., Shrestha, S. et al. “Implementation and Validation of Non-Uniform Body Region Specific 3D Age Scaling Factors (ASF) to Scale Whole-Body Computed Tomography (CT) Anatomy to Any Arbitrary Age” AAPM 2021, [ Discussion + Poster]
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Bates J, Shrestha, S. et al. “Low Dose Radiation to Cardiac Substructures and Late Onset Cardiac Disease: A Report from the Childhood Cancer Survivor Study (CCSS)” ASCO 2021, [ Discussion + Poster]
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A Gupta, C Owens, S Shrestha et al.” Investigation on the use of our 3D age scaling factors/functions (ASF) to scale whole-body regions to any arbitrary age” Med Phys. 2020; 47; 6: e806-e807 [E-Poster]
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C Owens*, A Gupta, S Shrestha et al. “Development of an Age-Scalable Colon Model with Substructures for Colon Radiation Therapy Dosimetry in Large Pediatric Cohorts for Late-Effects Studies” Med Phys. 2020; 47; 6: e743-e744 [E-Poster]
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A Gupta, C Owens, S Shrestha et al. “Development of Patient Height-Specific 3D Age-Scaling Factors to Generate DICOM Computational Phantoms for Retrospective Late-Effects Studies” Med Phys. 2020; 47; 6: e746 [E-Poster]
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Owens, C.*, Gupta, A.C., Shrestha, S., et al. “Development of a colon model for colon dosimetry in late effect studies” International Society for Radiation, Epidemiology and Dosimetry (ISORED) 2020, Sitges, Spain [Short Oral + Discussion + Poster]
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Gupta, A.C., Qiao, Y., Shrestha, S. et al. “On the Implementation and Validation of 3D Computational Pediatric Phantoms in Commercial TPS” Radiotherapy and Oncology, Volume 152, S702 - S703, ESTRO Congress 2020 [Poster]
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Gupta, A.C., Shrestha, S. et al., “An age scalable 3D computational phantom in DICOM standard for late effects studies”, South West American Association of Physicist in Medicine, SWAAPM 2020 [Poster Presentation]
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Gupta, A.*, Ying, Q., Lee, C., Ditty, C., Smith, S., Weathers, R., Shrestha, S. et al., “Implementation of 3D Computational Human Phantoms in RayStation for Retrospective Studies in Late Effects”. Med Phys. 2019; 46; 6: e586 [E-Poster]
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Hernandez, S.*, Weathers, R., Gupta, A., Shrestha, S et al. “Liver Dose Estimation for a PENTEC Late Effects Study”. Med Phys. 2019; 46; 6: e585 [E-Poster Presentation]
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Newhauser, W.D., Schneider, C., Wilson, L., Shrestha, S., Lis, M. and Donahue, W., (2017). Modeling of risk of secondary cancer from radiotherapy, 13th NEUDOS Symposium; May 14-16,2017; Krakow, Poland [Oral Presentation]
PEER REVIEWED ABSTRACTS
RESEARCH SUPPORT
PRESENT
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Title: Influence of Radiotherapy Dose to Cardiac Substructures on Cardiac Risk in Long-term Survivors of Childhood Cancer
Study Source: Childhood Cancer Survivor Study (co-PIs': Bates & Howell)
Role: Investigator
Link: https://ccss.stjude.org/content/dam/en_US/shared/ccss/documents/aoi/concept-proposal%2019-16.pdf
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Title: Risk Score Algorithm to Predict Individual Risk of Future Serious Late Cardiovascular Disease that includes Dose and Dose Volume Metrics for the Whole Heart and Heart Substructures
Study Source: Childhood Cancer Survivor Study (co-PIs': Howell & Mulrooney)
Role: Investigator
Link: https://ccss.stjude.org/content/dam/en_US/shared/ccss/documents/aoi/20191115
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PAST
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Title: Enhancing heart model of current CCSS age-specific computational phantoms by defining cardiac substructures and dose reconstruction
Funding Source: Childhood Cancer Survivor Study Career Development Award, NCI
Role: Principal Investigator (Trainee)
Link: https://ccss.stjude.org/career-development-award.html
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Title: Therapy Related Cardiac Risk in Childhood Cancer Survivors
Funding Source: UT Health Graduate School of Biomedical Sciences, Marilyn and Frederick R. Lummis, Jr. M.D. Fellowship
Role: Principal Investigator (Fellow)
MEDIA MENTIONS
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Shrestha's PhD Research praised on world stage; Cardiac Model Praised Physics World
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Shrestha awarded Landauer Sr. Fellowship: HPS
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Physics in the pandemic: Physics World Shrestha
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Shrestha receives Career Development Award , GSBS
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Shrestha awarded CCSS Career Development Award, St. Jude
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Shrestha receives Marilyn and Frederick R. Lummis, Jr. M.D., Fellowship GSBS
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Shrestha awarded Sylvan Rodrigue Sylvan Rodriguez Foundation Scholarship honoring George M. Stancel, Ph.D., GSBS
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Shrestha Expanding Horizon Grant Experience, AAPM Newsletter (Page 77-78)